![]() ![]() Sensors were gently applied to the skin surfaces and allowed to slowly adapt by adhesion forces. pH sensor foils (SF-HP5R PreSens GmbH, Regensburg, Germany) were preconditioned in Ringer solution (Merck, Germany) for at least 5 min prior to use. Luminescent 2D imaging of pH ss was done via RGB imaging. Prior research of our study group examined the effect of a pH 4 water-in-oil (W/O) emulsion as well as a 10% α-hydroxy acid O/W emulsion on pH ss and pH sc in healthy subjects and diabetics. Several target groups that may profit from these products in particular have been defined in other studies (e.g., elderly, patients with atopic dermatitis, diabetics). ![]() These findings have led to the development of acidic skin care products. Therefore, it is not surprising that many cutaneous diseases (e.g., atopic dermatitis, acne, ichthyosis, and mycotic infections) seem to be associated with an increased pH ss. showed that increased pH ss affects epidermal barrier function and SC integrity/cohesion. For example, alkalization of the skin surface can be caused by endogenous and exogenous factors, such as sweat, sebum, occlusive dressings, cleansers, particular soap bars, and alkaline skin care products. PH ss can, however, be altered by multiple factors. Conclusions: The tested pH 5 O/W emulsion seems to improve regeneration and stabilization of pH ss. 6.05 ± 0.03) (2) after washing, the treated area had a significantly lower pH ss than controls (6.13 ± 0.03 vs. Results: (1) 5 h after alkalization, the treated arm showed a significantly lower pH ss than the untreated one (5.87 ± 0.03 vs. Then, pH ss was measured before and after 5 min of washing a treated and an untreated area on the volar forearm. Experiment 2: study subjects used the emulsion twice daily for 1 week. Experiment 1: after defining the baseline pH ss, we alkalized the respective area and measured pH ss over a duration of 5 h, while applying emulsion every hour. Alkalization was reached by washing the volar forearm with a soap bar and warm running tap water for 20 min. In both experiments, 2D imaging with luminescent sensor foils was used to determine pH ss. Methods: We performed 2 experiments with 10 female study subjects in each. We tested a pH 5 oil-in-water (O/W) emulsion for pH ss regeneration and stabilization. In cases of increased pH ss, the acidity of the skin can be restored by topical formulations. Background: Human skin surface has a physiologically acidic pH (pH ss). ![]()
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